Chiasma

Newspaper reporting on events at the Boston University School of Medicine in the 1960s

Elite interviewing in professional organizations

Interviewing elites presents distinctive methodological challenges, which are exacerbated when interviewing elite professionals. These individuals (i.e. senior professionals and professionals in elite professional organizations) are typically relatively powerful, highly educated, and self-assured, and work in organizations which guard their external image very carefully. Over the past 25 years I have interviewed many hundreds of senior professionals in elite professional organizations. For this article, I have reflected on my experiences and have asked senior professionals to reflect on their own experience of research interviews. Bringing together insights of both interviewees and interviewers, this article provides an opportunity for researchers to reflect upon and improve their professional practice when conducting elite interviews

A flexible approach to parametric inference in nonlinear and time varying time series models

Many structural break and regime-switching models have been used with macroeconomic and …nancial data. In this paper, we develop an extremely flexible parametric model which can accommodate virtually any of these speci…cations and does so in a simple way which allows for straightforward Bayesian inference. The basic idea underlying our model is that it adds two simple concepts to a standard state space framework. These ideas are ordering and distance. By ordering the data in various ways, we can accommodate a wide variety of nonlinear time series models, including those with regime-switching and structural breaks. By allowing the state equation variances to depend on the distance between observations, the parameters can evolve in a wide variety of ways, allowing for everything from models exhibiting abrupt change (e.g. threshold autoregressive models or standard structural break models) to those which allow for a gradual evolution of parameters (e.g. smooth transition autoregressive models or time varying parameter models). We show how our model will (approximately) nest virtually every popular model in the regime-switching and structural break literatures. Bayesian econometric methods for inference in this model are developed. Because we stay within a state space framework, these methods are relatively straightforward, drawing on the existing literature. We use arti…cial data to show the advantages of our approach, before providing two empirical illustrations involving the modeling of real GDP growth

The North American and Pelican Nebulae I. IRAC Observations

We present a 9 deg^2 map of the North American and Pelican Nebulae regions obtained in all four IRAC channels with the Spitzer Space Telescope. The resulting photometry is merged with that at JHKs from 2MASS and a more spatially limited $BVI$ survey from previous ground-based work. We use a mixture of color- color diagrams to select a minimally contaminated set of more than 1600 objects that we claim are young stellar objects (YSOs) associated with the star forming region. Because our selection technique uses IR excess as a requirement, our sample is strongly biased against inclusion of Class III YSOs. The distribution of IRAC spectral slopes for our YSOs indicates that most of these objects are Class II, with a peak towards steeper spectral slopes but a substantial contribution from a tail of flat spectrum and Class I type objects. By studying the small fraction of the sample that is optically visible, we infer a typical age of a few Myr for the low mass population. The young stars are clustered, with about a third of them located in eight clusters that are located within or near the LDN 935 dark cloud. Half of the YSOs are located in regions with surface densities higher than 1000 YSOs / deg^2. The Class I objects are more clustered than the Class II stars.Comment: 16 pages, 12 figures, ApJ In pres

Solid State Physics

Contains research objectives and reports on four research projects

Semiparametric Bayesian inference in smooth coefficient models

We describe procedures for Bayesian estimation and testing in cross-sectional, panel data and nonlinear smooth coefficient models. The smooth coefficient model is a generalization of the partially linear or additive model wherein coefficients on linear explanatory variables are treated as unknown functions of an observable covariate. In the approach we describe, points on the regression lines are regarded as unknown parameters and priors are placed on differences between adjacent points to introduce the potential for smoothing the curves. The algorithms we describe are quite simple to implement - for example, estimation, testing and smoothing parameter selection can be carried out analytically in the cross-sectional smooth coefficient model. We apply our methods using data from the National Longitudinal Survey of Youth (NLSY). Using the NLSY data we first explore the relationship between ability and log wages and flexibly model how returns to schooling vary with measured cognitive ability. We also examine a model of female labor supply and use this example to illustrate how the described techniques can been applied in nonlinear settings

Recommendations for The Conduct of Economic Evaluations in Osteoporosis: Outcomes of An Experts’ Consensus Meeting Organized by The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) And the US Branch of The International Osteoporosis Foundation

Summary Economic evaluations are increasingly used to assess the value of health interventions, but variable quality and heterogeneity limit the use of these evaluations by decision-makers. These recommendations provide guidance for the design, conduct, and reporting of economic evaluations in osteoporosis to improve their transparency, comparability, and methodologic standards. Introduction This paper aims to provide recommendations for the conduct of economic evaluations in osteoporosis in order to improve their transparency, comparability, and methodologic standards. Methods A working group was convened by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis to make recommendations for the design, conduct, and reporting of economic evaluations in osteoporosis, to define an osteoporosis-specific reference case to serve a minimum standard for all economic analyses in osteoporosis, to discuss methodologic challenges and initiate a call for research. A literature review, a face-to-face meeting in New York City (including 11 experts), and a review/approval by a larger group of experts worldwide (including 23 experts in total) were conducted. Results Recommendations on the type of economic evaluation, methods for economic evaluation, modeling aspects, base-case analysis and population, excess mortality, fracture costs and disutility, treatment characteristics, and model validation were provided. Recommendations for reporting economic evaluations in osteoporosis were also made and an osteoporosis-specific checklist was designed that includes items to report when performing an economic evaluation in osteoporosis. Further, 12 minimum criteria for economic evaluations in osteoporosis were identified and 12 methodologic challenges and need for further research were discussed. Conclusion While the working group acknowledges challenges and the need for further research, these recommendations are intended to supplement general and national guidelines for economic evaluations, improve transparency, quality, and comparability of economic evaluations in osteoporosis, and maintain methodologic standards to increase their use by decision-makers

The philosophy of critical realism and childhood studies

Critical realism is a philosophy of social science that analyses and aims to remedy current problems and gaps. Basic tenets of positivist and quantitative research tend to contradict those of qualitative and interpretive research, and critical realism proposes ways to resolve the contradictions. Vital themes in childhood research that are reviewed in this article include a comparison with feminist research, critical realism, being and thought, transitive and intransitive, theory/practice consistency, agency and structure, closed and open systems, micro and macro in the global/local nexus, four planar social being, facts and values, and transformative change through the four-stage MELD dialectic. Critical realism aims to understand the world in order to be able move from coercion towards creative liberating power